Legal-status tracker
Every FDA action, dated and sourced
A dated log of every FDA and Federal Register action affecting compounded peptides and incretins, each row linked to its primary source. Checked daily.
We publish an action only after a person has read the source it links. An advisory committee voting in favour of a substance is not the FDA adding it to a list, and this page will never blur the two. Back to the compound reference.
Current status by compound
| Compound | Status | As of | Evidence |
|---|---|---|---|
| Semaglutide | FDA-approved product exists | 2026-09-02 | A |
| Tirzepatide | FDA-approved product exists | 2026-09-02 | A |
| Estradiol | FDA-approved product exists | 2026-09-02 | A |
| Progesterone | FDA-approved product exists | 2026-09-02 | A |
| PT-141 | FDA-approved product exists | 2026-09-02 | A |
| NAD+ | Not verified | — | A |
| Sermorelin | Not verified | — | — |
| GHK-Cu | Not verified | — | B |
| Glutathione | Not verified | — | A |
| Low-Dose Naltrexone | Not verified | — | A |
| BPC-157 | PCAC recommended — FDA has not acted | 2026-07-23 | C |
| Retatrutide | Not compoundable | 2026-09-02 | A |
| TB-500 | PCAC recommended — FDA has not acted | 2026-07-23 | B |
| Testosterone | FDA-approved product exists | 2026-09-02 | A |
| Epitalon | PCAC recommended — FDA has not acted | 2026-07-24 | A |
| KPV | PCAC recommended — FDA has not acted | 2026-07-23 | A |
| Liraglutide | FDA-approved product exists | 2026-09-02 | A |
| Metformin | FDA-approved product exists | 2026-09-02 | A |
| MOTS-c | PCAC recommended — FDA has not acted | 2026-07-23 | A |
| Rapamycin | FDA-approved product exists | 2026-09-02 | A |
| Semax | PCAC recommended — FDA has not acted | 2026-07-24 | B |
| Tesamorelin | FDA-approved product exists | 2026-09-02 | — |
| Anastrozole | FDA-approved product exists | 2026-09-02 | A |
| DSIP | PCAC voted against | 2026-07-24 | A |
| Dulaglutide | FDA-approved product exists | 2026-09-02 | A |
| Methylene Blue | FDA-approved product exists | 2026-09-02 | A |
| NMN | Not verified | — | A |
| Oxytocin | FDA-approved product exists | 2026-09-02 | A |
| CJC-1295 | Not verified | — | B |
| Enclomiphene | Not verified | — | A |
| Exenatide | FDA-approved product exists | 2026-09-02 | A |
| Ipamorelin | Not verified | — | A |
| MK-677 | Not verified | — | A |
| Nicotinamide Riboside | Not verified | — | A |
| Thymosin Alpha-1 | Not verified | — | A |
| 5-Amino-1MQ | Not verified | — | C |
| AOD-9604 | Not verified | — | C |
| Cagrilintide | Not verified | — | A |
| DHEA | Not verified | — | A |
| GHRP-2 | Not verified | — | A |
| GHRP-6 | Not verified | — | A |
| hCG | Not verified | — | A |
| IGF-1 LR3 | Not verified | — | E |
| Melanotan II | Not verified | — | A |
| Selank | Not verified | — | A |
| SS-31 | Not verified | — | A |
| Thymosin Beta-4 | Not verified | — | A |
| Urolithin A | Not verified | — | A |
| ARA-290 | Not verified | — | A |
| Cerebrolysin | Not verified | — | A |
| Dihexa | Not verified | — | C |
| Hexarelin | Not verified | — | A |
| Humanin | Not verified | — | A |
| Kisspeptin-10 | Not verified | — | — |
| Larazotide | Not verified | — | A |
| LL-37 | Not verified | — | A |
| Mazdutide | Not verified | — | A |
| P21 | Not verified | — | A |
| Pentosan Polysulfate | Not verified | — | A |
| Spermidine | Not verified | — | A |
| Survodutide | Not verified | — | A |
Action log (24)
- OtherRetatrutide
Retatrutide is an investigational drug in active clinical trials (verified 2026-09-02)
Not approved and not compoundable. Material sold online as retatrutide is outside the regulated supply chain.
ClinicalTrials.gov - FDA-approved labellingAnastrozole
FDA-approved labelling containing Anastrozole is on file with DailyMed (verified 2026-09-02)
An FDA-approved product with this active ingredient is available by prescription.
DailyMed (NLM) - FDA-approved labellingMethylene Blue
FDA-approved labelling containing Methylene Blue is on file with DailyMed (verified 2026-09-02)
An FDA-approved product with this active ingredient is available by prescription.
DailyMed (NLM) - FDA-approved labellingOxytocin
FDA-approved labelling containing Oxytocin is on file with DailyMed (verified 2026-09-02)
An FDA-approved product with this active ingredient is available by prescription.
DailyMed (NLM) - FDA-approved labellingMetformin
FDA-approved labelling containing Metformin is on file with DailyMed (verified 2026-09-02)
An FDA-approved product with this active ingredient is available by prescription.
DailyMed (NLM) - FDA-approved labellingRapamycin
FDA-approved labelling containing Rapamycin is on file with DailyMed (verified 2026-09-02)
An FDA-approved product with this active ingredient is available by prescription.
DailyMed (NLM) - FDA-approved labellingTestosterone
FDA-approved labelling containing Testosterone is on file with DailyMed (verified 2026-09-02)
An FDA-approved product with this active ingredient is available by prescription.
DailyMed (NLM) - FDA-approved labellingProgesterone
FDA-approved labelling containing Progesterone is on file with DailyMed (verified 2026-09-02)
An FDA-approved product with this active ingredient is available by prescription.
DailyMed (NLM) - FDA-approved labellingEstradiol
FDA-approved labelling containing Estradiol is on file with DailyMed (verified 2026-09-02)
An FDA-approved product with this active ingredient is available by prescription.
DailyMed (NLM) - FDA-approved labellingPT-141
FDA-approved labelling containing PT-141 is on file with DailyMed (verified 2026-09-02)
An FDA-approved product with this active ingredient is available by prescription.
DailyMed (NLM) - FDA-approved labellingTesamorelin
FDA-approved labelling containing Tesamorelin is on file with DailyMed (verified 2026-09-02)
An FDA-approved product with this active ingredient is available by prescription.
DailyMed (NLM) - FDA-approved labellingExenatide
FDA-approved labelling containing Exenatide is on file with DailyMed (verified 2026-09-02)
An FDA-approved product with this active ingredient is available by prescription.
DailyMed (NLM) - FDA-approved labellingDulaglutide
FDA-approved labelling containing Dulaglutide is on file with DailyMed (verified 2026-09-02)
An FDA-approved product with this active ingredient is available by prescription.
DailyMed (NLM) - FDA-approved labellingLiraglutide
FDA-approved labelling containing Liraglutide is on file with DailyMed (verified 2026-09-02)
An FDA-approved product with this active ingredient is available by prescription.
DailyMed (NLM) - FDA-approved labellingTirzepatide
FDA-approved labelling containing Tirzepatide is on file with DailyMed (verified 2026-09-02)
An FDA-approved product with this active ingredient is available by prescription.
DailyMed (NLM) - FDA-approved labellingSemaglutide
FDA-approved labelling containing Semaglutide is on file with DailyMed (verified 2026-09-02)
An FDA-approved product with this active ingredient is available by prescription.
DailyMed (NLM) - PCAC voteEpitalon
Advisory committee reportedly voted 7-4-1 in favour of including Epitalon on the 503A bulk drug substances list
Advisory vote only, as reported. FDA has not added it to the list, and the substance is not FDA-approved.
Healio (2026-07-24) - PCAC voteSemax
Advisory committee reportedly voted 8-5-1 in favour of including Semax on the 503A bulk drug substances list
Advisory vote only, as reported. FDA has not added it to the list, and the substance is not FDA-approved.
Healio (2026-07-24) - PCAC voteDSIP
Advisory committee reportedly voted 6-7-1 against including DSIP on the 503A bulk drug substances list
The committee reportedly did not support inclusion. The substance remains off the 503A list and is not FDA-approved.
Healio (2026-07-24) - PCAC voteMOTS-c
Advisory committee reportedly voted 7-5-2 in favour of including MOTS-c on the 503A bulk drug substances list
Advisory vote only, as reported. FDA has not added it to the list, and the substance is not FDA-approved.
Healio (2026-07-24) - PCAC voteTB-500
Advisory committee reportedly voted 8-6-1 in favour of including TB-500 on the 503A bulk drug substances list
Advisory vote only, as reported. FDA has not added it to the list, and the substance is not FDA-approved.
Healio (2026-07-24) - PCAC voteKPV
Advisory committee reportedly voted 8-6-1 in favour of including KPV on the 503A bulk drug substances list
Advisory vote only, as reported. FDA has not added it to the list, and the substance is not FDA-approved.
Healio (2026-07-24) - PCAC voteBPC-157
Advisory committee reportedly voted 8-6-1 in favour of including BPC-157 on the 503A bulk drug substances list
Advisory vote only, as reported. FDA has not added it to the list, and the substance is not FDA-approved.
Healio (2026-07-24) - PCAC voteBPC-157, TB-500, Epitalon, KPV, MOTS-c, Semax, DSIP
FDA convened the Pharmacy Compounding Advisory Committee to consider seven peptide bulk drug substances for the 503A list
The meeting establishes that these substances were formally considered. It does not change any substance's status.
FDA Advisory Committee Calendar
Educational information, not legal or medical advice. Compounded drugs are not FDA-approved and are not reviewed by the FDA for safety, effectiveness, or manufacturing quality. If you know of an action missing here, tell us and we will add it with its citation.