Spark
Low desire is often a brain-signalling problem, not a blood-flow one. Spark is physician-prescribed PT-141 (bremelanotide), which works on the melanocortin pathways behind desire itself, taken on-demand and monitored by your doctor. Bremelanotide is FDA-approved only as the branded Vyleesi injector, for premenopausal women; Chia dispenses a compounded bremelanotide nasal spray, which is not FDA-approved, and use in men or after menopause is off-label.
Same day prescription
FDA-regulated sources
US-licensed longevity doctors
FSA/HSA eligible
10,000+ people exploring health with us
What's in this protocol:
Desire, at its source.
PT-141 works on the desire pathway
Unlike erection-focused drugs that act on blood flow, bremelanotide activates melanocortin receptors in the brain — the circuitry behind wanting to, not just being able to. In its branded injectable form it is FDA-approved for low sexual desire in premenopausal women, and it has been studied in men.
On-demand, for women and men
Taken as needed roughly 45 minutes before intimacy rather than every day, as a needle-free at-home nasal spray. One therapy, studied in both women and men — no daily pill to remember.
One physician, one coordinated plan
PT-141 can transiently raise blood pressure and cause nausea, so your Chia physician screens your cardiovascular history, sets the right dose and route, and monitors you — it's not avoided or unsupervised.
How it works
Take the 2-min health quiz
Provider reviews & approves
Compound is prepared & shipped
Track & optimize with your doctor
Every batch tested
U.S.-licensed
Regulated sources
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What patients are saying
4.9 out of 5 from 256 reviews
"After two kids and a decade of marriage, desire had just quietly left the building. This is the first thing that brought back the spark of actually wanting to, not just going along with it."
Renee K.
"I was skeptical that a shot could change something so mental. But it's not about plumbing — it's the interest that came back. My wife noticed before I said anything."
Daniel P.
"The on-demand part matters to me — I didn't want another daily pill. I use it before date night and it does what my doctor said it would."
Marco T.
"First time I had some nausea, so we adjusted the timing and dose. Since then it's been smooth, and the difference in how present I feel is real."
Alyssa M.
"I'd tried the blue-pill route and it fixed the wrong problem. This works on wanting to in the first place, which turned out to be what was actually missing."
Grant H.
"My husband and I did this together, both curious. It reopened a part of our relationship we'd both stopped bringing up. Worth the awkward first conversation with the doctor."
Priscilla D.
"Stress and antidepressants had dialed me down to zero. Under my doctor's guidance, this gave me back a baseline of interest I thought was gone for good."
Nadia F.
"After two kids and a decade of marriage, desire had just quietly left the building. This is the first thing that brought back the spark of actually wanting to, not just going along with it."
Renee K.
"I was skeptical that a shot could change something so mental. But it's not about plumbing — it's the interest that came back. My wife noticed before I said anything."
Daniel P.
"The on-demand part matters to me — I didn't want another daily pill. I use it before date night and it does what my doctor said it would."
Marco T.
"First time I had some nausea, so we adjusted the timing and dose. Since then it's been smooth, and the difference in how present I feel is real."
Alyssa M.
"I'd tried the blue-pill route and it fixed the wrong problem. This works on wanting to in the first place, which turned out to be what was actually missing."
Grant H.
"My husband and I did this together, both curious. It reopened a part of our relationship we'd both stopped bringing up. Worth the awkward first conversation with the doctor."
Priscilla D.
"Stress and antidepressants had dialed me down to zero. Under my doctor's guidance, this gave me back a baseline of interest I thought was gone for good."
Nadia F.
"After two kids and a decade of marriage, desire had just quietly left the building. This is the first thing that brought back the spark of actually wanting to, not just going along with it."
Renee K.
"I was skeptical that a shot could change something so mental. But it's not about plumbing — it's the interest that came back. My wife noticed before I said anything."
Daniel P.
"The on-demand part matters to me — I didn't want another daily pill. I use it before date night and it does what my doctor said it would."
Marco T.
"First time I had some nausea, so we adjusted the timing and dose. Since then it's been smooth, and the difference in how present I feel is real."
Alyssa M.
"I'd tried the blue-pill route and it fixed the wrong problem. This works on wanting to in the first place, which turned out to be what was actually missing."
Grant H.
"My husband and I did this together, both curious. It reopened a part of our relationship we'd both stopped bringing up. Worth the awkward first conversation with the doctor."
Priscilla D.
"Stress and antidepressants had dialed me down to zero. Under my doctor's guidance, this gave me back a baseline of interest I thought was gone for good."
Nadia F.
"After two kids and a decade of marriage, desire had just quietly left the building. This is the first thing that brought back the spark of actually wanting to, not just going along with it."
Renee K.
"I was skeptical that a shot could change something so mental. But it's not about plumbing — it's the interest that came back. My wife noticed before I said anything."
Daniel P.
"The on-demand part matters to me — I didn't want another daily pill. I use it before date night and it does what my doctor said it would."
Marco T.
"First time I had some nausea, so we adjusted the timing and dose. Since then it's been smooth, and the difference in how present I feel is real."
Alyssa M.
"I'd tried the blue-pill route and it fixed the wrong problem. This works on wanting to in the first place, which turned out to be what was actually missing."
Grant H.
"My husband and I did this together, both curious. It reopened a part of our relationship we'd both stopped bringing up. Worth the awkward first conversation with the doctor."
Priscilla D.
"Stress and antidepressants had dialed me down to zero. Under my doctor's guidance, this gave me back a baseline of interest I thought was gone for good."
Nadia F.
"After two kids and a decade of marriage, desire had just quietly left the building. This is the first thing that brought back the spark of actually wanting to, not just going along with it."
Renee K.
"I was skeptical that a shot could change something so mental. But it's not about plumbing — it's the interest that came back. My wife noticed before I said anything."
Daniel P.
"The on-demand part matters to me — I didn't want another daily pill. I use it before date night and it does what my doctor said it would."
Marco T.
"First time I had some nausea, so we adjusted the timing and dose. Since then it's been smooth, and the difference in how present I feel is real."
Alyssa M.
"I'd tried the blue-pill route and it fixed the wrong problem. This works on wanting to in the first place, which turned out to be what was actually missing."
Grant H.
"My husband and I did this together, both curious. It reopened a part of our relationship we'd both stopped bringing up. Worth the awkward first conversation with the doctor."
Priscilla D.
"Stress and antidepressants had dialed me down to zero. Under my doctor's guidance, this gave me back a baseline of interest I thought was gone for good."
Nadia F.
"After two kids and a decade of marriage, desire had just quietly left the building. This is the first thing that brought back the spark of actually wanting to, not just going along with it."
Renee K.
"I was skeptical that a shot could change something so mental. But it's not about plumbing — it's the interest that came back. My wife noticed before I said anything."
Daniel P.
"The on-demand part matters to me — I didn't want another daily pill. I use it before date night and it does what my doctor said it would."
Marco T.
"First time I had some nausea, so we adjusted the timing and dose. Since then it's been smooth, and the difference in how present I feel is real."
Alyssa M.
"I'd tried the blue-pill route and it fixed the wrong problem. This works on wanting to in the first place, which turned out to be what was actually missing."
Grant H.
"My husband and I did this together, both curious. It reopened a part of our relationship we'd both stopped bringing up. Worth the awkward first conversation with the doctor."
Priscilla D.
"Stress and antidepressants had dialed me down to zero. Under my doctor's guidance, this gave me back a baseline of interest I thought was gone for good."
Nadia F.
"After two kids and a decade of marriage, desire had just quietly left the building. This is the first thing that brought back the spark of actually wanting to, not just going along with it."
Renee K.
"I was skeptical that a shot could change something so mental. But it's not about plumbing — it's the interest that came back. My wife noticed before I said anything."
Daniel P.
"The on-demand part matters to me — I didn't want another daily pill. I use it before date night and it does what my doctor said it would."
Marco T.
"First time I had some nausea, so we adjusted the timing and dose. Since then it's been smooth, and the difference in how present I feel is real."
Alyssa M.
"I'd tried the blue-pill route and it fixed the wrong problem. This works on wanting to in the first place, which turned out to be what was actually missing."
Grant H.
"My husband and I did this together, both curious. It reopened a part of our relationship we'd both stopped bringing up. Worth the awkward first conversation with the doctor."
Priscilla D.
"Stress and antidepressants had dialed me down to zero. Under my doctor's guidance, this gave me back a baseline of interest I thought was gone for good."
Nadia F.
"After two kids and a decade of marriage, desire had just quietly left the building. This is the first thing that brought back the spark of actually wanting to, not just going along with it."
Renee K.
"I was skeptical that a shot could change something so mental. But it's not about plumbing — it's the interest that came back. My wife noticed before I said anything."
Daniel P.
"The on-demand part matters to me — I didn't want another daily pill. I use it before date night and it does what my doctor said it would."
Marco T.
"First time I had some nausea, so we adjusted the timing and dose. Since then it's been smooth, and the difference in how present I feel is real."
Alyssa M.
"I'd tried the blue-pill route and it fixed the wrong problem. This works on wanting to in the first place, which turned out to be what was actually missing."
Grant H.
"My husband and I did this together, both curious. It reopened a part of our relationship we'd both stopped bringing up. Worth the awkward first conversation with the doctor."
Priscilla D.
"Stress and antidepressants had dialed me down to zero. Under my doctor's guidance, this gave me back a baseline of interest I thought was gone for good."
Nadia F.
"Stress and antidepressants had dialed me down to zero. Under my doctor's guidance, this gave me back a baseline of interest I thought was gone for good."
Nadia F.
"My husband and I did this together, both curious. It reopened a part of our relationship we'd both stopped bringing up. Worth the awkward first conversation with the doctor."
Priscilla D.
"I'd tried the blue-pill route and it fixed the wrong problem. This works on wanting to in the first place, which turned out to be what was actually missing."
Grant H.
"First time I had some nausea, so we adjusted the timing and dose. Since then it's been smooth, and the difference in how present I feel is real."
Alyssa M.
"The on-demand part matters to me — I didn't want another daily pill. I use it before date night and it does what my doctor said it would."
Marco T.
"I was skeptical that a shot could change something so mental. But it's not about plumbing — it's the interest that came back. My wife noticed before I said anything."
Daniel P.
"After two kids and a decade of marriage, desire had just quietly left the building. This is the first thing that brought back the spark of actually wanting to, not just going along with it."
Renee K.
"Stress and antidepressants had dialed me down to zero. Under my doctor's guidance, this gave me back a baseline of interest I thought was gone for good."
Nadia F.
"My husband and I did this together, both curious. It reopened a part of our relationship we'd both stopped bringing up. Worth the awkward first conversation with the doctor."
Priscilla D.
"I'd tried the blue-pill route and it fixed the wrong problem. This works on wanting to in the first place, which turned out to be what was actually missing."
Grant H.
"First time I had some nausea, so we adjusted the timing and dose. Since then it's been smooth, and the difference in how present I feel is real."
Alyssa M.
"The on-demand part matters to me — I didn't want another daily pill. I use it before date night and it does what my doctor said it would."
Marco T.
"I was skeptical that a shot could change something so mental. But it's not about plumbing — it's the interest that came back. My wife noticed before I said anything."
Daniel P.
"After two kids and a decade of marriage, desire had just quietly left the building. This is the first thing that brought back the spark of actually wanting to, not just going along with it."
Renee K.
"Stress and antidepressants had dialed me down to zero. Under my doctor's guidance, this gave me back a baseline of interest I thought was gone for good."
Nadia F.
"My husband and I did this together, both curious. It reopened a part of our relationship we'd both stopped bringing up. Worth the awkward first conversation with the doctor."
Priscilla D.
"I'd tried the blue-pill route and it fixed the wrong problem. This works on wanting to in the first place, which turned out to be what was actually missing."
Grant H.
"First time I had some nausea, so we adjusted the timing and dose. Since then it's been smooth, and the difference in how present I feel is real."
Alyssa M.
"The on-demand part matters to me — I didn't want another daily pill. I use it before date night and it does what my doctor said it would."
Marco T.
"I was skeptical that a shot could change something so mental. But it's not about plumbing — it's the interest that came back. My wife noticed before I said anything."
Daniel P.
"After two kids and a decade of marriage, desire had just quietly left the building. This is the first thing that brought back the spark of actually wanting to, not just going along with it."
Renee K.
"Stress and antidepressants had dialed me down to zero. Under my doctor's guidance, this gave me back a baseline of interest I thought was gone for good."
Nadia F.
"My husband and I did this together, both curious. It reopened a part of our relationship we'd both stopped bringing up. Worth the awkward first conversation with the doctor."
Priscilla D.
"I'd tried the blue-pill route and it fixed the wrong problem. This works on wanting to in the first place, which turned out to be what was actually missing."
Grant H.
"First time I had some nausea, so we adjusted the timing and dose. Since then it's been smooth, and the difference in how present I feel is real."
Alyssa M.
"The on-demand part matters to me — I didn't want another daily pill. I use it before date night and it does what my doctor said it would."
Marco T.
"I was skeptical that a shot could change something so mental. But it's not about plumbing — it's the interest that came back. My wife noticed before I said anything."
Daniel P.
"After two kids and a decade of marriage, desire had just quietly left the building. This is the first thing that brought back the spark of actually wanting to, not just going along with it."
Renee K.
Individual results may vary.
Frequently asked questionsquestions
Spark is physician-prescribed PT-141 (bremelanotide) for low sexual desire — in women and men. Unlike erection drugs that act on blood flow, PT-141 works on the melanocortin pathways in the brain behind desire itself. Bremelanotide is FDA-approved only as the branded Vyleesi injector for premenopausal women. Chia dispenses a compounded bremelanotide nasal spray, which is not FDA-approved; use in men or after menopause is off-label. In two phase-3 trials it significantly improved desire and reduced the distress around it versus placebo (Obstetrics & Gynecology, 2019).
Erection medications (the Viagra class) work on the physical response — blood flow. Spark works earlier: PT-141 activates melanocortin-4 receptors in the central nervous system, the circuitry behind wanting to (Journal of Sexual Medicine, 2016). When the missing piece is desire rather than mechanics, that's a different — and often more relevant — target. Some people use them for different problems.
Yes. PT-141 is FDA-approved for low sexual desire only in premenopausal women. In men, use is off-label and investigational: subcutaneous bremelanotide produced erectile responses in early controlled studies (International Journal of Impotence Research, 2004), but it is not an FDA-approved or proven treatment for men. It's one of the few desire therapies studied across genders — one treatment, both partners if you choose.
PT-141 is taken on-demand — about 45 minutes before intimacy — not every day. Chia prescribes it as a needle-free nasal spray you use at home, with the dose set by your physician. Because it's used as needed, there's no daily medication to remember.
The most common side effect is transient nausea, often managed by adjusting dose or timing. PT-141 can briefly raise blood pressure, so it's avoided in uncontrolled hypertension or cardiovascular disease, and a US-licensed Chia physician screens your history, sets the dose, and monitors you (Obstetrics & Gynecology, 2019). After your intake, a clinician reviews your profile, typically within 24 hours; if you're not eligible, you won't be charged.
Yes — Spark is FSA/HSA eligible; pay with your HSA/FSA card at checkout and email support@chia.health if your administrator needs documentation. You can cancel anytime through your patient portal. Before your consultation, before your first shipment, or if you're found ineligible, you get a full refund; month-to-month plans include a 30-day money-back refund on unused monthly plans. Details at chia.health/legal/refund-policy.