GLP-1 + Sermorelin
GLP-1 is the most effective weight-loss therapy available — but rapid loss can strip lean muscle along with fat. This protocol pairs GLP-1 with sermorelin to restore your natural growth-hormone rhythm, helping preserve lean mass and recovery while the weight comes off.
Same day prescription
FDA-regulated sources
US-licensed longevity doctors
FSA/HSA eligible
10,000+ people exploring health with us
What's in this protocol:
GLP-1
Physician-prescribed GLP-1 therapy — your provider selects semaglutide or tirzepatide based on your health profile.
Sermorelin
A GHRH analog that prompts the pituitary to release growth hormone in its natural, pulsatile rhythm — studied for body composition, recovery and sleep quality.
Lose fat and hold onto muscle.
GLP-1 drives the weight loss
By acting on your appetite hormones, GLP-1 therapy produces the largest, best-evidenced weight loss of any injectable — the engine of this protocol.
Sermorelin helps preserve lean muscle
Rapid weight loss risks taking lean mass with the fat. Sermorelin restores your natural growth-hormone pulse, which supports muscle maintenance, recovery and sleep during a calorie deficit.
One physician, one coordinated plan
Your Chia physician doses and monitors both compounds as one plan — GLP-1 titration and sermorelin are adjusted together, never as two disconnected prescriptions.
How it works
Take the 2–min health quiz
US licensed doctor reviews & approves
Treatment is shipped in discreet packaging
Track & optimize with your doctor
Every batch tested
U.S.-licensed
Regulated sources
Uncover Your Longevity Potential
Getting started is risk-free. Upload your labs and we'll track them — 40+ biomarkers, reviewed by a licensed provider to personalize your plan.
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What patients are saying
4.9 out of 5
"The food noise thing is real. I used to plan lunch while eating breakfast. Somewhere in the first month that background chatter just shut off, and now I can sit through a movie without plotting a snack run."
Paul D.
"I stalled for eight months on my old plan. Six weeks after switching to tirzepatide, the scale finally remembered which direction it's supposed to go."
Felicia M.
"My ring has me averaging 40 more minutes of deep sleep than my baseline. Took about five weeks to show up, and the better mornings followed a week after that."
Trent A.
"The vending machine at 2pm owned me for years — I teach middle school, it's right outside my room. Down 17 pounds since February, and I walk right past it now."
Monica V.
"As an accountant I appreciate compounding, and that's what this feels like — small weekly losses that quietly add up. Twenty-six pounds since the fall, no drama."
Stuart P.
"I'm 48. Lifting what my son's college buddies lift isn't the goal — being able to lift again Thursday after lifting Tuesday is. That gap closed around month two."
Doug E.
"We went up in dose slower than the forums recommend, and I'm glad. My stomach never staged a protest, and the scale kept moving anyway."
Henry C.
"The hunger didn't just get quieter, it got reasonable. I eat when my body asks, not when my brain throws a tantrum in a parking lot outside a drive-thru."
Yvonne D.
"Nothing dramatic happened, which is sort of the point. I just stopped dreading the alarm. A month and a half in, waking up feels like surfacing instead of clawing."
Naomi H.
"Sixty-two years old and I've done every diet since Atkins was new. This is the first time the weight came off without my whole personality becoming about food."
Gail W.
"My fasting glucose had crept up at every physical for five years. This year it finally went the other way, and my doctor and I just sort of grinned at each other."
Alan H.
"Night-shift dispatcher, ten years, and my sleep has been broken the whole time. It's not fixed — but I'm getting deeper stretches than I've had in ages, and I'm less of a zombie by Friday."
Colleen R.
"I track everything — calories, steps, sleep. What actually changed is I stopped eating at 9pm out of boredom. The data says 14 pounds in three months; the win is the quiet evenings."
Priya N.
"I'm a wedding photographer, on my feet ten hours every Saturday. Carrying 24 fewer pounds through a reception changes how Sunday feels."
Jordan S.
"Ten seconds before bed — that's the entire routine. Two months in, I recover from a weekend of yard work like it's no big deal again."
Pete Y.
"Half a plate at dinner and I'm done. My husband finishes my fries now, which he considers a feature of the whole arrangement."
Tina B.
"Honestly, the first month was an adjustment — I had to learn to eat slower and stop when full. Once I did, it's been the steadiest progress of my adult life."
Carmen R.
"I gave it three months before judging, like my doctor asked. Verdict: deeper sleep, fewer 3am ceiling-staring sessions, and my fingers don't ache after climbing days."
Marisol G.
"I drive a delivery route, and gas station food was most of my diet. The cravings dropped off around week five. I pack a lunch now because I finally get a vote."
Marcus J.
"I picked the dual-pathway option because I wanted my best shot on the first try. Five months in, my tailor has taken in the same suit twice."
Desmond L.
"My trainer takes measurements quarterly, and this quarter lean mass ticked up while nothing in my routine changed. She asked what I was doing differently. The answer is: sleeping."
Brendan W.
"I won't pretend it's effortless — I still have to choose the salad. But the shot took the desperation out of the choosing. Nineteen pounds down in five months."
Beth O.
"My watch says my resting heart rate has dropped six beats since March. I'm sure the twenty pounds has something to do with it. Correlation, causation, whatever — I'll take it."
Holly E.
"I bragged for years about getting by on five hours. Ninety days in, I sleep seven and guard it — turns out I was just used to feeling bad."
Omar Z.
"Stairs stopped being a negotiation somewhere around the 15-pound mark. Nobody told me that part would feel bigger than the number on the scale."
Ron K.
"The cravings used to win every road trip. Last month I drove to Tucson and back, and the rest-stop candy aisle had nothing to say to me."
Ray V.
"Mid-fifties, and sleep had become a rumor I'd heard about. It took most of two months to notice anything, but the nights run deeper now and pickleball doesn't wreck me for days."
Lynette C.
"A coworker had a rough first month on it, so I braced for the worst. Mine was milder — some queasiness early, then nothing. My bloodwork at three months looked better across the board."
Denise F.
"I'm 55 and was tired of being told to just eat less, as if I hadn't tried that for thirty years. This actually changed the inputs. Down 31 pounds and still going, slowly."
Wanda C.
"What sold me is that it nudges my own system instead of overriding it. The change has been slow and steady — better sleep first, then easier recovery. That pace suits me fine."
Garrett M.
"The food noise thing is real. I used to plan lunch while eating breakfast. Somewhere in the first month that background chatter just shut off, and now I can sit through a movie without plotting a snack run."
Paul D.
"I stalled for eight months on my old plan. Six weeks after switching to tirzepatide, the scale finally remembered which direction it's supposed to go."
Felicia M.
"My ring has me averaging 40 more minutes of deep sleep than my baseline. Took about five weeks to show up, and the better mornings followed a week after that."
Trent A.
"The vending machine at 2pm owned me for years — I teach middle school, it's right outside my room. Down 17 pounds since February, and I walk right past it now."
Monica V.
"As an accountant I appreciate compounding, and that's what this feels like — small weekly losses that quietly add up. Twenty-six pounds since the fall, no drama."
Stuart P.
"I'm 48. Lifting what my son's college buddies lift isn't the goal — being able to lift again Thursday after lifting Tuesday is. That gap closed around month two."
Doug E.
"We went up in dose slower than the forums recommend, and I'm glad. My stomach never staged a protest, and the scale kept moving anyway."
Henry C.
"The hunger didn't just get quieter, it got reasonable. I eat when my body asks, not when my brain throws a tantrum in a parking lot outside a drive-thru."
Yvonne D.
"Nothing dramatic happened, which is sort of the point. I just stopped dreading the alarm. A month and a half in, waking up feels like surfacing instead of clawing."
Naomi H.
"Sixty-two years old and I've done every diet since Atkins was new. This is the first time the weight came off without my whole personality becoming about food."
Gail W.
"My fasting glucose had crept up at every physical for five years. This year it finally went the other way, and my doctor and I just sort of grinned at each other."
Alan H.
"Night-shift dispatcher, ten years, and my sleep has been broken the whole time. It's not fixed — but I'm getting deeper stretches than I've had in ages, and I'm less of a zombie by Friday."
Colleen R.
"I track everything — calories, steps, sleep. What actually changed is I stopped eating at 9pm out of boredom. The data says 14 pounds in three months; the win is the quiet evenings."
Priya N.
"I'm a wedding photographer, on my feet ten hours every Saturday. Carrying 24 fewer pounds through a reception changes how Sunday feels."
Jordan S.
"Ten seconds before bed — that's the entire routine. Two months in, I recover from a weekend of yard work like it's no big deal again."
Pete Y.
"Half a plate at dinner and I'm done. My husband finishes my fries now, which he considers a feature of the whole arrangement."
Tina B.
"Honestly, the first month was an adjustment — I had to learn to eat slower and stop when full. Once I did, it's been the steadiest progress of my adult life."
Carmen R.
"I gave it three months before judging, like my doctor asked. Verdict: deeper sleep, fewer 3am ceiling-staring sessions, and my fingers don't ache after climbing days."
Marisol G.
"I drive a delivery route, and gas station food was most of my diet. The cravings dropped off around week five. I pack a lunch now because I finally get a vote."
Marcus J.
"I picked the dual-pathway option because I wanted my best shot on the first try. Five months in, my tailor has taken in the same suit twice."
Desmond L.
"My trainer takes measurements quarterly, and this quarter lean mass ticked up while nothing in my routine changed. She asked what I was doing differently. The answer is: sleeping."
Brendan W.
"I won't pretend it's effortless — I still have to choose the salad. But the shot took the desperation out of the choosing. Nineteen pounds down in five months."
Beth O.
"My watch says my resting heart rate has dropped six beats since March. I'm sure the twenty pounds has something to do with it. Correlation, causation, whatever — I'll take it."
Holly E.
"I bragged for years about getting by on five hours. Ninety days in, I sleep seven and guard it — turns out I was just used to feeling bad."
Omar Z.
"Stairs stopped being a negotiation somewhere around the 15-pound mark. Nobody told me that part would feel bigger than the number on the scale."
Ron K.
"The cravings used to win every road trip. Last month I drove to Tucson and back, and the rest-stop candy aisle had nothing to say to me."
Ray V.
"Mid-fifties, and sleep had become a rumor I'd heard about. It took most of two months to notice anything, but the nights run deeper now and pickleball doesn't wreck me for days."
Lynette C.
"A coworker had a rough first month on it, so I braced for the worst. Mine was milder — some queasiness early, then nothing. My bloodwork at three months looked better across the board."
Denise F.
"I'm 55 and was tired of being told to just eat less, as if I hadn't tried that for thirty years. This actually changed the inputs. Down 31 pounds and still going, slowly."
Wanda C.
"What sold me is that it nudges my own system instead of overriding it. The change has been slow and steady — better sleep first, then easier recovery. That pace suits me fine."
Garrett M.
"The food noise thing is real. I used to plan lunch while eating breakfast. Somewhere in the first month that background chatter just shut off, and now I can sit through a movie without plotting a snack run."
Paul D.
"My ring has me averaging 40 more minutes of deep sleep than my baseline. Took about five weeks to show up, and the better mornings followed a week after that."
Trent A.
"As an accountant I appreciate compounding, and that's what this feels like — small weekly losses that quietly add up. Twenty-six pounds since the fall, no drama."
Stuart P.
"We went up in dose slower than the forums recommend, and I'm glad. My stomach never staged a protest, and the scale kept moving anyway."
Henry C.
"Nothing dramatic happened, which is sort of the point. I just stopped dreading the alarm. A month and a half in, waking up feels like surfacing instead of clawing."
Naomi H.
"My fasting glucose had crept up at every physical for five years. This year it finally went the other way, and my doctor and I just sort of grinned at each other."
Alan H.
"I track everything — calories, steps, sleep. What actually changed is I stopped eating at 9pm out of boredom. The data says 14 pounds in three months; the win is the quiet evenings."
Priya N.
"Ten seconds before bed — that's the entire routine. Two months in, I recover from a weekend of yard work like it's no big deal again."
Pete Y.
"Honestly, the first month was an adjustment — I had to learn to eat slower and stop when full. Once I did, it's been the steadiest progress of my adult life."
Carmen R.
"I drive a delivery route, and gas station food was most of my diet. The cravings dropped off around week five. I pack a lunch now because I finally get a vote."
Marcus J.
"My trainer takes measurements quarterly, and this quarter lean mass ticked up while nothing in my routine changed. She asked what I was doing differently. The answer is: sleeping."
Brendan W.
"My watch says my resting heart rate has dropped six beats since March. I'm sure the twenty pounds has something to do with it. Correlation, causation, whatever — I'll take it."
Holly E.
"Stairs stopped being a negotiation somewhere around the 15-pound mark. Nobody told me that part would feel bigger than the number on the scale."
Ron K.
"Mid-fifties, and sleep had become a rumor I'd heard about. It took most of two months to notice anything, but the nights run deeper now and pickleball doesn't wreck me for days."
Lynette C.
"I'm 55 and was tired of being told to just eat less, as if I hadn't tried that for thirty years. This actually changed the inputs. Down 31 pounds and still going, slowly."
Wanda C.
"The food noise thing is real. I used to plan lunch while eating breakfast. Somewhere in the first month that background chatter just shut off, and now I can sit through a movie without plotting a snack run."
Paul D.
"My ring has me averaging 40 more minutes of deep sleep than my baseline. Took about five weeks to show up, and the better mornings followed a week after that."
Trent A.
"As an accountant I appreciate compounding, and that's what this feels like — small weekly losses that quietly add up. Twenty-six pounds since the fall, no drama."
Stuart P.
"We went up in dose slower than the forums recommend, and I'm glad. My stomach never staged a protest, and the scale kept moving anyway."
Henry C.
"Nothing dramatic happened, which is sort of the point. I just stopped dreading the alarm. A month and a half in, waking up feels like surfacing instead of clawing."
Naomi H.
"My fasting glucose had crept up at every physical for five years. This year it finally went the other way, and my doctor and I just sort of grinned at each other."
Alan H.
"I track everything — calories, steps, sleep. What actually changed is I stopped eating at 9pm out of boredom. The data says 14 pounds in three months; the win is the quiet evenings."
Priya N.
"Ten seconds before bed — that's the entire routine. Two months in, I recover from a weekend of yard work like it's no big deal again."
Pete Y.
"Honestly, the first month was an adjustment — I had to learn to eat slower and stop when full. Once I did, it's been the steadiest progress of my adult life."
Carmen R.
"I drive a delivery route, and gas station food was most of my diet. The cravings dropped off around week five. I pack a lunch now because I finally get a vote."
Marcus J.
"My trainer takes measurements quarterly, and this quarter lean mass ticked up while nothing in my routine changed. She asked what I was doing differently. The answer is: sleeping."
Brendan W.
"My watch says my resting heart rate has dropped six beats since March. I'm sure the twenty pounds has something to do with it. Correlation, causation, whatever — I'll take it."
Holly E.
"Stairs stopped being a negotiation somewhere around the 15-pound mark. Nobody told me that part would feel bigger than the number on the scale."
Ron K.
"Mid-fifties, and sleep had become a rumor I'd heard about. It took most of two months to notice anything, but the nights run deeper now and pickleball doesn't wreck me for days."
Lynette C.
"I'm 55 and was tired of being told to just eat less, as if I hadn't tried that for thirty years. This actually changed the inputs. Down 31 pounds and still going, slowly."
Wanda C.
"I stalled for eight months on my old plan. Six weeks after switching to tirzepatide, the scale finally remembered which direction it's supposed to go."
Felicia M.
"The vending machine at 2pm owned me for years — I teach middle school, it's right outside my room. Down 17 pounds since February, and I walk right past it now."
Monica V.
"I'm 48. Lifting what my son's college buddies lift isn't the goal — being able to lift again Thursday after lifting Tuesday is. That gap closed around month two."
Doug E.
"The hunger didn't just get quieter, it got reasonable. I eat when my body asks, not when my brain throws a tantrum in a parking lot outside a drive-thru."
Yvonne D.
"Sixty-two years old and I've done every diet since Atkins was new. This is the first time the weight came off without my whole personality becoming about food."
Gail W.
"Night-shift dispatcher, ten years, and my sleep has been broken the whole time. It's not fixed — but I'm getting deeper stretches than I've had in ages, and I'm less of a zombie by Friday."
Colleen R.
"I'm a wedding photographer, on my feet ten hours every Saturday. Carrying 24 fewer pounds through a reception changes how Sunday feels."
Jordan S.
"Half a plate at dinner and I'm done. My husband finishes my fries now, which he considers a feature of the whole arrangement."
Tina B.
"I gave it three months before judging, like my doctor asked. Verdict: deeper sleep, fewer 3am ceiling-staring sessions, and my fingers don't ache after climbing days."
Marisol G.
"I picked the dual-pathway option because I wanted my best shot on the first try. Five months in, my tailor has taken in the same suit twice."
Desmond L.
"I won't pretend it's effortless — I still have to choose the salad. But the shot took the desperation out of the choosing. Nineteen pounds down in five months."
Beth O.
"I bragged for years about getting by on five hours. Ninety days in, I sleep seven and guard it — turns out I was just used to feeling bad."
Omar Z.
"The cravings used to win every road trip. Last month I drove to Tucson and back, and the rest-stop candy aisle had nothing to say to me."
Ray V.
"A coworker had a rough first month on it, so I braced for the worst. Mine was milder — some queasiness early, then nothing. My bloodwork at three months looked better across the board."
Denise F.
"What sold me is that it nudges my own system instead of overriding it. The change has been slow and steady — better sleep first, then easier recovery. That pace suits me fine."
Garrett M.
"I stalled for eight months on my old plan. Six weeks after switching to tirzepatide, the scale finally remembered which direction it's supposed to go."
Felicia M.
"The vending machine at 2pm owned me for years — I teach middle school, it's right outside my room. Down 17 pounds since February, and I walk right past it now."
Monica V.
"I'm 48. Lifting what my son's college buddies lift isn't the goal — being able to lift again Thursday after lifting Tuesday is. That gap closed around month two."
Doug E.
"The hunger didn't just get quieter, it got reasonable. I eat when my body asks, not when my brain throws a tantrum in a parking lot outside a drive-thru."
Yvonne D.
"Sixty-two years old and I've done every diet since Atkins was new. This is the first time the weight came off without my whole personality becoming about food."
Gail W.
"Night-shift dispatcher, ten years, and my sleep has been broken the whole time. It's not fixed — but I'm getting deeper stretches than I've had in ages, and I'm less of a zombie by Friday."
Colleen R.
"I'm a wedding photographer, on my feet ten hours every Saturday. Carrying 24 fewer pounds through a reception changes how Sunday feels."
Jordan S.
"Half a plate at dinner and I'm done. My husband finishes my fries now, which he considers a feature of the whole arrangement."
Tina B.
"I gave it three months before judging, like my doctor asked. Verdict: deeper sleep, fewer 3am ceiling-staring sessions, and my fingers don't ache after climbing days."
Marisol G.
"I picked the dual-pathway option because I wanted my best shot on the first try. Five months in, my tailor has taken in the same suit twice."
Desmond L.
"I won't pretend it's effortless — I still have to choose the salad. But the shot took the desperation out of the choosing. Nineteen pounds down in five months."
Beth O.
"I bragged for years about getting by on five hours. Ninety days in, I sleep seven and guard it — turns out I was just used to feeling bad."
Omar Z.
"The cravings used to win every road trip. Last month I drove to Tucson and back, and the rest-stop candy aisle had nothing to say to me."
Ray V.
"A coworker had a rough first month on it, so I braced for the worst. Mine was milder — some queasiness early, then nothing. My bloodwork at three months looked better across the board."
Denise F.
"What sold me is that it nudges my own system instead of overriding it. The change has been slow and steady — better sleep first, then easier recovery. That pace suits me fine."
Garrett M.
Individual results may vary.
Frequently asked questionsquestions
It's our flagship weight-loss stack: your GLP-1 (semaglutide or tirzepatide) drives the fat loss while sermorelin helps you keep your muscle. GLP-1 acts on your appetite hormones to produce the largest, best-evidenced weight loss of any injectable. Rapid loss risks stripping lean mass along with fat, so sermorelin restores your natural growth-hormone pulse to support muscle maintenance, recovery and sleep during the calorie deficit.
Rapid weight loss risks taking lean mass with the fat. Sermorelin prompts your pituitary to release growth hormone in its natural, pulsatile rhythm — over 16 weeks in adults aged 55–71, nightly GHRH raised IGF-1 and added lean muscle in the men (J Clin Endocrinol Metab, 1997). It supports the muscle maintenance, recovery and deeper sleep a calorie deficit tends to undermine.
Your GLP-1 (semaglutide or tirzepatide) is the engine — it reduces appetite to produce the weight loss, with semaglutide averaging 14.9% body-weight loss over 68 weeks (New England Journal of Medicine, 2021). Sermorelin restores your natural growth-hormone rhythm to help preserve lean muscle, aid recovery from training, and support deeper, more restorative slow-wave sleep.
The two evidence tiers differ, and we're honest about that. GLP-1 weight loss rests on some of the largest, most rigorous trials in metabolic medicine. Sermorelin's human studies are smaller and older, pointing more to how it works — restoring GH pulses to support lean mass and sleep — than to proven long-term outcomes. Together they pair a proven weight-loss engine with muscle-preservation support.
Yes. Your Chia physician doses and monitors both compounds as one plan — GLP-1 titration and sermorelin are adjusted together, never as two disconnected prescriptions. All Chia clinicians are US-licensed. After your intake, a clinician reviews your profile, typically within 24 hours, and you keep ongoing portal access for progress tracking and questions at no extra cost.
Both compounds are FSA/HSA eligible — pay with your HSA/FSA card at checkout. You can cancel anytime through your portal; before your consultation, before your first shipment, or if you're found ineligible, you get a full refund. Month-to-month plans include a 30-day money-back refund on unused monthly plans. See chia.health/legal/refund-policy for full details.