ProgesteroneBalance the estrogen. Sleep through the night.
Bioidentical progesterone that supports sleep and balances estrogen — an oral capsule or cream, with only the oral capsule protecting the uterine lining alongside estrogen.
Same day prescription
FDA-regulated sources
US-licensed physicians
FSA/HSA eligible
Progesterone works even harder in combination
Most patients who take Progesterone have more than one goal. These physician-curated protocols pair it with other compounds — supervised by one physician, delivered as one plan.
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Progesterone benefitsProgesterone treatment benefits
Only oral micronized progesterone protects the uterine lining — the cream is not a substitute for women with a uterus on estrogen.
Oral micronized progesterone supports deeper, calmer sleep
Balances estrogen as part of a complete hormone plan
Taken as an oral capsule or a topical cream, prescribed by your physician
How it works
Take the 2-min health quiz
Provider reviews & approves
Compound is prepared & shipped
Track & optimize with your doctor
Every batch tested
U.S.-licensed
Regulated sourcesThe science behind progesterone
Micronized progesterone is bioidentical to the hormone your body makes. Paired with estrogen it protects the uterine lining, and its oral form is mildly sedating — an evidence-backed part of menopausal hormone therapy.
Protects the uterine lining
In the PEPI trial, adding micronized progesterone to estrogen protected the endometrium from the overgrowth unopposed estrogen can cause, in women with a uterus (JAMA, 1996).
Supports sleep
Oral micronized progesterone taken at bedtime improved sleep quality in postmenopausal women, likely through its calming metabolites (Menopause / sleep studies).
A gentler progestogen
Large cohort data suggest micronized progesterone carries a more favorable breast profile than older synthetic progestins (E3N cohort, 2008).
Bioidentical by design
Micronized progesterone is molecularly identical to the progesterone your ovaries produce, unlike synthetic progestins — the basis for its use in modern menopausal therapy.
Clinically validated. Physician monitored.
Micronized progesterone is bioidentical to the hormone your body makes. Paired with estrogen it protects the uterine lining, and its oral form is mildly sedating — an evidence-backed part of menopausal hormone therapy.
Protects the uterine lining
In the PEPI trial, adding micronized progesterone to estrogen protected the endometrium from the overgrowth unopposed estrogen can cause, in women with a uterus (JAMA, 1996).
Supports sleep
Oral micronized progesterone taken at bedtime improved sleep quality in postmenopausal women, likely through its calming metabolites (Menopause / sleep studies).
A gentler progestogen
Large cohort data suggest micronized progesterone carries a more favorable breast profile than older synthetic progestins (E3N cohort, 2008).
Bioidentical by design
Micronized progesterone is molecularly identical to the progesterone your ovaries produce, unlike synthetic progestins — the basis for its use in modern menopausal therapy.
What patients are saying
4.9 out of 5 from 256 reviews
"Adding progesterone at night was the piece that fixed my sleep. I take it before bed and I'm actually drowsy at a normal hour again."
Maureen F.
"My doctor was clear that with a uterus I needed progesterone alongside the estrogen, not just estrogen. I appreciated the honesty about why."
Colleen S.
"The oral capsule made me a little sleepy at first, which turned out to be exactly what my insomnia needed. Timing it at bedtime was the trick."
Ingrid P.
"Estrogen alone left me feeling a bit edgy. Once progesterone was added, everything evened out — mood, sleep, the whole picture."
Yolanda M.
"I asked specifically for bioidentical rather than the older synthetic kind, and that's what I got. It matters to me that it's the same molecule my body makes."
Ruth A.
"The cream option worked for me because I don't love swallowing pills. My physician adjusted the dose once and it's been smooth since."
Delia H.
"Between the estrogen and the progesterone, my night sweats and my 2am waking both settled down. It took a few weeks, but it held."
Fern C.
"I was nervous about hormones and my doctor talked me through the safety data on micronized progesterone specifically. That conversation is why I felt comfortable starting."
Loretta W.
"Adding progesterone at night was the piece that fixed my sleep. I take it before bed and I'm actually drowsy at a normal hour again."
Maureen F.
"My doctor was clear that with a uterus I needed progesterone alongside the estrogen, not just estrogen. I appreciated the honesty about why."
Colleen S.
"The oral capsule made me a little sleepy at first, which turned out to be exactly what my insomnia needed. Timing it at bedtime was the trick."
Ingrid P.
"Estrogen alone left me feeling a bit edgy. Once progesterone was added, everything evened out — mood, sleep, the whole picture."
Yolanda M.
"I asked specifically for bioidentical rather than the older synthetic kind, and that's what I got. It matters to me that it's the same molecule my body makes."
Ruth A.
"The cream option worked for me because I don't love swallowing pills. My physician adjusted the dose once and it's been smooth since."
Delia H.
"Between the estrogen and the progesterone, my night sweats and my 2am waking both settled down. It took a few weeks, but it held."
Fern C.
"I was nervous about hormones and my doctor talked me through the safety data on micronized progesterone specifically. That conversation is why I felt comfortable starting."
Loretta W.
"Adding progesterone at night was the piece that fixed my sleep. I take it before bed and I'm actually drowsy at a normal hour again."
Maureen F.
"The oral capsule made me a little sleepy at first, which turned out to be exactly what my insomnia needed. Timing it at bedtime was the trick."
Ingrid P.
"I asked specifically for bioidentical rather than the older synthetic kind, and that's what I got. It matters to me that it's the same molecule my body makes."
Ruth A.
"Between the estrogen and the progesterone, my night sweats and my 2am waking both settled down. It took a few weeks, but it held."
Fern C.
"Adding progesterone at night was the piece that fixed my sleep. I take it before bed and I'm actually drowsy at a normal hour again."
Maureen F.
"The oral capsule made me a little sleepy at first, which turned out to be exactly what my insomnia needed. Timing it at bedtime was the trick."
Ingrid P.
"I asked specifically for bioidentical rather than the older synthetic kind, and that's what I got. It matters to me that it's the same molecule my body makes."
Ruth A.
"Between the estrogen and the progesterone, my night sweats and my 2am waking both settled down. It took a few weeks, but it held."
Fern C.
"Adding progesterone at night was the piece that fixed my sleep. I take it before bed and I'm actually drowsy at a normal hour again."
Maureen F.
"The oral capsule made me a little sleepy at first, which turned out to be exactly what my insomnia needed. Timing it at bedtime was the trick."
Ingrid P.
"I asked specifically for bioidentical rather than the older synthetic kind, and that's what I got. It matters to me that it's the same molecule my body makes."
Ruth A.
"Between the estrogen and the progesterone, my night sweats and my 2am waking both settled down. It took a few weeks, but it held."
Fern C.
"Adding progesterone at night was the piece that fixed my sleep. I take it before bed and I'm actually drowsy at a normal hour again."
Maureen F.
"The oral capsule made me a little sleepy at first, which turned out to be exactly what my insomnia needed. Timing it at bedtime was the trick."
Ingrid P.
"I asked specifically for bioidentical rather than the older synthetic kind, and that's what I got. It matters to me that it's the same molecule my body makes."
Ruth A.
"Between the estrogen and the progesterone, my night sweats and my 2am waking both settled down. It took a few weeks, but it held."
Fern C.
"My doctor was clear that with a uterus I needed progesterone alongside the estrogen, not just estrogen. I appreciated the honesty about why."
Colleen S.
"Estrogen alone left me feeling a bit edgy. Once progesterone was added, everything evened out — mood, sleep, the whole picture."
Yolanda M.
"The cream option worked for me because I don't love swallowing pills. My physician adjusted the dose once and it's been smooth since."
Delia H.
"I was nervous about hormones and my doctor talked me through the safety data on micronized progesterone specifically. That conversation is why I felt comfortable starting."
Loretta W.
"My doctor was clear that with a uterus I needed progesterone alongside the estrogen, not just estrogen. I appreciated the honesty about why."
Colleen S.
"Estrogen alone left me feeling a bit edgy. Once progesterone was added, everything evened out — mood, sleep, the whole picture."
Yolanda M.
"The cream option worked for me because I don't love swallowing pills. My physician adjusted the dose once and it's been smooth since."
Delia H.
"I was nervous about hormones and my doctor talked me through the safety data on micronized progesterone specifically. That conversation is why I felt comfortable starting."
Loretta W.
"My doctor was clear that with a uterus I needed progesterone alongside the estrogen, not just estrogen. I appreciated the honesty about why."
Colleen S.
"Estrogen alone left me feeling a bit edgy. Once progesterone was added, everything evened out — mood, sleep, the whole picture."
Yolanda M.
"The cream option worked for me because I don't love swallowing pills. My physician adjusted the dose once and it's been smooth since."
Delia H.
"I was nervous about hormones and my doctor talked me through the safety data on micronized progesterone specifically. That conversation is why I felt comfortable starting."
Loretta W.
"My doctor was clear that with a uterus I needed progesterone alongside the estrogen, not just estrogen. I appreciated the honesty about why."
Colleen S.
"Estrogen alone left me feeling a bit edgy. Once progesterone was added, everything evened out — mood, sleep, the whole picture."
Yolanda M.
"The cream option worked for me because I don't love swallowing pills. My physician adjusted the dose once and it's been smooth since."
Delia H.
"I was nervous about hormones and my doctor talked me through the safety data on micronized progesterone specifically. That conversation is why I felt comfortable starting."
Loretta W.
Individual results may vary.
Frequently asked questions
Progesterone is a bioidentical hormone your ovaries make. In menopausal hormone therapy (HRT) it does two main jobs: for women with a uterus it protects the uterine lining when you're taking estrogen, and its oral form supports sleep. In the PEPI trial, adding micronized progesterone to estrogen protected the endometrium from the overgrowth unopposed estrogen can cause (JAMA, 1996).
If you have a uterus, yes — estrogen on its own can overstimulate the uterine lining, and progesterone protects against that, so the two are prescribed together. Endometrial protection is established only for oral micronized progesterone. Topical/cream progesterone does not reliably reach the uterine lining, so women with a uterus taking estrogen need the oral form for that protection — the cream is not a substitute. If you've had a hysterectomy, you may not need it. Your physician decides based on your anatomy and health history; it's part of tailoring the plan to you.
It's taken as an oral micronized capsule or a topical cream. The oral capsule is mildly sedating, so it's usually taken at bedtime — many women find it improves sleep quality as a welcome side benefit. Your physician sets the form, dose and timing for you.
Yes. Micronized progesterone is molecularly identical to the progesterone your body makes, unlike older synthetic progestins. Large cohort data suggest it carries a more favorable breast-cancer profile than synthetic options (E3N cohort, 2008), which is why it's preferred in modern bioidentical hormone therapy. We use the bioidentical form.
A licensed US clinician reviews your intake — typically within 24 hours — and prescribes progesterone as part of your hormone plan, often alongside estradiol. They may ask for a brief call first. Once approved, it ships to your door with tracking, and refill check-ins keep your therapy uninterrupted. If you're not a candidate, you won't be charged.
Yes — progesterone is FSA/HSA eligible; pay with your HSA/FSA card at checkout and email support@chia.health if your administrator needs documentation. You can cancel anytime through your patient portal. Before your consultation, before your first shipment, or if you're found ineligible, you get a full refund; we also offer a 30-day money-back refund on unused monthly plans. Details at chia.health/legal/refund-policy.
