Low-Dose NaltrexoneTurn down the inflammation dial.
A low, nightly dose of naltrexone studied for autoimmune conditions, chronic pain and inflammation — physician-prescribed and monitored.
Same day prescription
FDA-regulated sources
US-licensed physicians
FSA/HSA eligible
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Low-Dose Naltrexone benefitsLow-Dose Naltrexone treatment benefits
Studied for calming the immune signalling behind chronic inflammation
Investigated for fibromyalgia and chronic pain
May ease symptoms in autoimmune conditions
A single low-dose capsule at night — simple and inexpensive
How it works
Take the 2-min health quiz
Provider reviews & approves
Compound is prepared & shipped
Track & optimize with your doctor
Every batch tested
U.S.-licensed
Regulated sourcesThe science behind Low-Dose Naltrexone
Using low-dose naltrexone for autoimmune conditions, pain, or inflammation is off-label — it is not FDA-approved for these uses, and naltrexone blocks opioid pain medicine and can trigger sudden, severe withdrawal in anyone taking or dependent on opioids. At roughly a tenth of its addiction-treatment dose, naltrexone briefly blocks opioid receptors — a rebound that's studied for damping down the immune and glial signalling behind chronic pain and autoimmune inflammation. The human evidence is early but growing.
Fibromyalgia pain
In a placebo-controlled crossover trial, low-dose naltrexone reduced fibromyalgia pain and improved mood and life satisfaction versus placebo (Arthritis & Rheumatism, 2013).
Crohn's disease
In a placebo-controlled trial, low-dose naltrexone improved Crohn's disease activity and endoscopic healing in a majority of patients (Digestive Diseases and Sciences, 2011).
Calms glial inflammation
Reviews describe low-dose naltrexone acting on microglia and TLR4 signalling to lower neuroinflammation — the proposed mechanism behind its pain and autoimmune effects (Clinical Rheumatology, 2014).
Well-tolerated, low-cost
Across studies the most common side effects are vivid dreams and mild sleep disturbance early on; it's inexpensive and generally well tolerated under physician supervision (Clinical Rheumatology, 2014).
Clinically validated. Physician monitored.
Using low-dose naltrexone for autoimmune conditions, pain, or inflammation is off-label — it is not FDA-approved for these uses, and naltrexone blocks opioid pain medicine and can trigger sudden, severe withdrawal in anyone taking or dependent on opioids. At roughly a tenth of its addiction-treatment dose, naltrexone briefly blocks opioid receptors — a rebound that's studied for damping down the immune and glial signalling behind chronic pain and autoimmune inflammation. The human evidence is early but growing.
Fibromyalgia pain
In a placebo-controlled crossover trial, low-dose naltrexone reduced fibromyalgia pain and improved mood and life satisfaction versus placebo (Arthritis & Rheumatism, 2013).
Crohn's disease
In a placebo-controlled trial, low-dose naltrexone improved Crohn's disease activity and endoscopic healing in a majority of patients (Digestive Diseases and Sciences, 2011).
Calms glial inflammation
Reviews describe low-dose naltrexone acting on microglia and TLR4 signalling to lower neuroinflammation — the proposed mechanism behind its pain and autoimmune effects (Clinical Rheumatology, 2014).
Well-tolerated, low-cost
Across studies the most common side effects are vivid dreams and mild sleep disturbance early on; it's inexpensive and generally well tolerated under physician supervision (Clinical Rheumatology, 2014).
What patients are saying
4.9 out of 5 from 256 reviews
"Fibromyalgia had me rationing my energy by the hour. A couple of months on LDN and the baseline ache is quieter — not gone, but I get more good hours than bad now."
Deborah S.
"The vivid dreams the first two weeks were wild, then they settled. What stayed is less all-over inflammation and a bit more energy to get through my day."
Helena V.
"I'd tried a lot of expensive things for chronic pain. A tiny cheap capsule at bedtime doing this much still surprises me. I take it with my doctor watching the details."
Curtis L.
"Crohn's has run my life for years. LDN isn't a cure, but paired with my regimen my last scope looked better than it has in a long time."
Yara N.
"My joints felt like they belonged to someone twenty years older. Three months in, morning stiffness is noticeably shorter. I'm careful to credit the whole plan, not just one pill."
Gwen A.
"What I appreciate is how boring it is — one capsule at night, no drama, and slowly the inflammation dial turned down. My doctor kept the dose dialed in for me."
Isaac M.
"Fibromyalgia had me rationing my energy by the hour. A couple of months on LDN and the baseline ache is quieter — not gone, but I get more good hours than bad now."
Deborah S.
"The vivid dreams the first two weeks were wild, then they settled. What stayed is less all-over inflammation and a bit more energy to get through my day."
Helena V.
"I'd tried a lot of expensive things for chronic pain. A tiny cheap capsule at bedtime doing this much still surprises me. I take it with my doctor watching the details."
Curtis L.
"Crohn's has run my life for years. LDN isn't a cure, but paired with my regimen my last scope looked better than it has in a long time."
Yara N.
"My joints felt like they belonged to someone twenty years older. Three months in, morning stiffness is noticeably shorter. I'm careful to credit the whole plan, not just one pill."
Gwen A.
"What I appreciate is how boring it is — one capsule at night, no drama, and slowly the inflammation dial turned down. My doctor kept the dose dialed in for me."
Isaac M.
"Fibromyalgia had me rationing my energy by the hour. A couple of months on LDN and the baseline ache is quieter — not gone, but I get more good hours than bad now."
Deborah S.
"The vivid dreams the first two weeks were wild, then they settled. What stayed is less all-over inflammation and a bit more energy to get through my day."
Helena V.
"I'd tried a lot of expensive things for chronic pain. A tiny cheap capsule at bedtime doing this much still surprises me. I take it with my doctor watching the details."
Curtis L.
"Crohn's has run my life for years. LDN isn't a cure, but paired with my regimen my last scope looked better than it has in a long time."
Yara N.
"My joints felt like they belonged to someone twenty years older. Three months in, morning stiffness is noticeably shorter. I'm careful to credit the whole plan, not just one pill."
Gwen A.
"What I appreciate is how boring it is — one capsule at night, no drama, and slowly the inflammation dial turned down. My doctor kept the dose dialed in for me."
Isaac M.
"Fibromyalgia had me rationing my energy by the hour. A couple of months on LDN and the baseline ache is quieter — not gone, but I get more good hours than bad now."
Deborah S.
"The vivid dreams the first two weeks were wild, then they settled. What stayed is less all-over inflammation and a bit more energy to get through my day."
Helena V.
"I'd tried a lot of expensive things for chronic pain. A tiny cheap capsule at bedtime doing this much still surprises me. I take it with my doctor watching the details."
Curtis L.
"Crohn's has run my life for years. LDN isn't a cure, but paired with my regimen my last scope looked better than it has in a long time."
Yara N.
"My joints felt like they belonged to someone twenty years older. Three months in, morning stiffness is noticeably shorter. I'm careful to credit the whole plan, not just one pill."
Gwen A.
"What I appreciate is how boring it is — one capsule at night, no drama, and slowly the inflammation dial turned down. My doctor kept the dose dialed in for me."
Isaac M.
"Fibromyalgia had me rationing my energy by the hour. A couple of months on LDN and the baseline ache is quieter — not gone, but I get more good hours than bad now."
Deborah S.
"The vivid dreams the first two weeks were wild, then they settled. What stayed is less all-over inflammation and a bit more energy to get through my day."
Helena V.
"I'd tried a lot of expensive things for chronic pain. A tiny cheap capsule at bedtime doing this much still surprises me. I take it with my doctor watching the details."
Curtis L.
"Crohn's has run my life for years. LDN isn't a cure, but paired with my regimen my last scope looked better than it has in a long time."
Yara N.
"My joints felt like they belonged to someone twenty years older. Three months in, morning stiffness is noticeably shorter. I'm careful to credit the whole plan, not just one pill."
Gwen A.
"What I appreciate is how boring it is — one capsule at night, no drama, and slowly the inflammation dial turned down. My doctor kept the dose dialed in for me."
Isaac M.
"Fibromyalgia had me rationing my energy by the hour. A couple of months on LDN and the baseline ache is quieter — not gone, but I get more good hours than bad now."
Deborah S.
"The vivid dreams the first two weeks were wild, then they settled. What stayed is less all-over inflammation and a bit more energy to get through my day."
Helena V.
"I'd tried a lot of expensive things for chronic pain. A tiny cheap capsule at bedtime doing this much still surprises me. I take it with my doctor watching the details."
Curtis L.
"Crohn's has run my life for years. LDN isn't a cure, but paired with my regimen my last scope looked better than it has in a long time."
Yara N.
"My joints felt like they belonged to someone twenty years older. Three months in, morning stiffness is noticeably shorter. I'm careful to credit the whole plan, not just one pill."
Gwen A.
"What I appreciate is how boring it is — one capsule at night, no drama, and slowly the inflammation dial turned down. My doctor kept the dose dialed in for me."
Isaac M.
"Fibromyalgia had me rationing my energy by the hour. A couple of months on LDN and the baseline ache is quieter — not gone, but I get more good hours than bad now."
Deborah S.
"The vivid dreams the first two weeks were wild, then they settled. What stayed is less all-over inflammation and a bit more energy to get through my day."
Helena V.
"I'd tried a lot of expensive things for chronic pain. A tiny cheap capsule at bedtime doing this much still surprises me. I take it with my doctor watching the details."
Curtis L.
"Crohn's has run my life for years. LDN isn't a cure, but paired with my regimen my last scope looked better than it has in a long time."
Yara N.
"My joints felt like they belonged to someone twenty years older. Three months in, morning stiffness is noticeably shorter. I'm careful to credit the whole plan, not just one pill."
Gwen A.
"What I appreciate is how boring it is — one capsule at night, no drama, and slowly the inflammation dial turned down. My doctor kept the dose dialed in for me."
Isaac M.
"Fibromyalgia had me rationing my energy by the hour. A couple of months on LDN and the baseline ache is quieter — not gone, but I get more good hours than bad now."
Deborah S.
"The vivid dreams the first two weeks were wild, then they settled. What stayed is less all-over inflammation and a bit more energy to get through my day."
Helena V.
"I'd tried a lot of expensive things for chronic pain. A tiny cheap capsule at bedtime doing this much still surprises me. I take it with my doctor watching the details."
Curtis L.
"Crohn's has run my life for years. LDN isn't a cure, but paired with my regimen my last scope looked better than it has in a long time."
Yara N.
"My joints felt like they belonged to someone twenty years older. Three months in, morning stiffness is noticeably shorter. I'm careful to credit the whole plan, not just one pill."
Gwen A.
"What I appreciate is how boring it is — one capsule at night, no drama, and slowly the inflammation dial turned down. My doctor kept the dose dialed in for me."
Isaac M.
"What I appreciate is how boring it is — one capsule at night, no drama, and slowly the inflammation dial turned down. My doctor kept the dose dialed in for me."
Isaac M.
"My joints felt like they belonged to someone twenty years older. Three months in, morning stiffness is noticeably shorter. I'm careful to credit the whole plan, not just one pill."
Gwen A.
"Crohn's has run my life for years. LDN isn't a cure, but paired with my regimen my last scope looked better than it has in a long time."
Yara N.
"I'd tried a lot of expensive things for chronic pain. A tiny cheap capsule at bedtime doing this much still surprises me. I take it with my doctor watching the details."
Curtis L.
"The vivid dreams the first two weeks were wild, then they settled. What stayed is less all-over inflammation and a bit more energy to get through my day."
Helena V.
"Fibromyalgia had me rationing my energy by the hour. A couple of months on LDN and the baseline ache is quieter — not gone, but I get more good hours than bad now."
Deborah S.
"What I appreciate is how boring it is — one capsule at night, no drama, and slowly the inflammation dial turned down. My doctor kept the dose dialed in for me."
Isaac M.
"My joints felt like they belonged to someone twenty years older. Three months in, morning stiffness is noticeably shorter. I'm careful to credit the whole plan, not just one pill."
Gwen A.
"Crohn's has run my life for years. LDN isn't a cure, but paired with my regimen my last scope looked better than it has in a long time."
Yara N.
"I'd tried a lot of expensive things for chronic pain. A tiny cheap capsule at bedtime doing this much still surprises me. I take it with my doctor watching the details."
Curtis L.
"The vivid dreams the first two weeks were wild, then they settled. What stayed is less all-over inflammation and a bit more energy to get through my day."
Helena V.
"Fibromyalgia had me rationing my energy by the hour. A couple of months on LDN and the baseline ache is quieter — not gone, but I get more good hours than bad now."
Deborah S.
"What I appreciate is how boring it is — one capsule at night, no drama, and slowly the inflammation dial turned down. My doctor kept the dose dialed in for me."
Isaac M.
"My joints felt like they belonged to someone twenty years older. Three months in, morning stiffness is noticeably shorter. I'm careful to credit the whole plan, not just one pill."
Gwen A.
"Crohn's has run my life for years. LDN isn't a cure, but paired with my regimen my last scope looked better than it has in a long time."
Yara N.
"I'd tried a lot of expensive things for chronic pain. A tiny cheap capsule at bedtime doing this much still surprises me. I take it with my doctor watching the details."
Curtis L.
"The vivid dreams the first two weeks were wild, then they settled. What stayed is less all-over inflammation and a bit more energy to get through my day."
Helena V.
"Fibromyalgia had me rationing my energy by the hour. A couple of months on LDN and the baseline ache is quieter — not gone, but I get more good hours than bad now."
Deborah S.
"What I appreciate is how boring it is — one capsule at night, no drama, and slowly the inflammation dial turned down. My doctor kept the dose dialed in for me."
Isaac M.
"My joints felt like they belonged to someone twenty years older. Three months in, morning stiffness is noticeably shorter. I'm careful to credit the whole plan, not just one pill."
Gwen A.
"Crohn's has run my life for years. LDN isn't a cure, but paired with my regimen my last scope looked better than it has in a long time."
Yara N.
"I'd tried a lot of expensive things for chronic pain. A tiny cheap capsule at bedtime doing this much still surprises me. I take it with my doctor watching the details."
Curtis L.
"The vivid dreams the first two weeks were wild, then they settled. What stayed is less all-over inflammation and a bit more energy to get through my day."
Helena V.
"Fibromyalgia had me rationing my energy by the hour. A couple of months on LDN and the baseline ache is quieter — not gone, but I get more good hours than bad now."
Deborah S.
Individual results may vary.
Frequently asked questions
LDN is naltrexone taken at roughly a tenth of its usual dose. At that low dose it briefly blocks opioid receptors, producing a rebound that's studied for calming the immune and glial signalling behind chronic pain and autoimmune inflammation. In a placebo-controlled crossover trial, it reduced fibromyalgia pain and improved mood versus placebo (Arthritis & Rheumatism, 2013).
It's most studied for fibromyalgia and chronic pain, and for autoimmune and inflammatory conditions. Using LDN for autoimmune conditions, pain, or inflammation is off-label — it is not FDA-approved for these uses. In a placebo-controlled trial, LDN improved Crohn's disease activity and endoscopic healing in a majority of patients (Digestive Diseases and Sciences, 2011). Reviews describe it acting on microglia and TLR4 signalling to lower neuroinflammation (Clinical Rheumatology, 2014). The human evidence is early but growing, and we frame it honestly.
LDN is taken once nightly as a single low-dose capsule. Your physician starts you at a low dose and adjusts gradually. It's inexpensive and simple — most of the effect builds over weeks rather than days, so consistency matters.
Across studies the most common side effects are vivid dreams and mild sleep disturbance in the first couple of weeks, which usually settle. It's generally well tolerated and low-cost under physician supervision (Clinical Rheumatology, 2014). Important safety warning: using LDN for autoimmune conditions, pain, or inflammation is off-label — it is not FDA-approved for these uses. Naltrexone blocks opioid pain medication and can trigger sudden, severe opioid withdrawal in anyone taking or dependent on opioids, so tell your physician about every medication you take.
It's suited to people dealing with autoimmune conditions, chronic inflammation, or persistent pain such as fibromyalgia — often as part of a broader plan rather than a standalone cure. To start, take the 2-minute health quiz. A licensed US clinician reviews your history and current medications, typically within 24 hours, and recommends whether LDN fits your profile and state requirements before anything ships.
LDN may be FSA/HSA eligible with a valid prescription — check with your plan administrator. Pay with your HSA/FSA card at checkout and email support@chia.health if your administrator needs documentation. You can cancel anytime through your patient portal. Before your consultation, before your first shipment, or if a provider finds you're not eligible, you get a full refund; we also offer a 30-day money-back refund on unused monthly plans. Details at chia.health/legal/refund-policy.
